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KMID : 0043320040270121290
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Archives of Pharmacal Research
2004 Volume.27 No. 12 p.1290 ~ p.1294
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Determination of Stability Constants of the Inclusion Complexes of β-Blockers in Heptakis (2,3-Dimethyl-6-Sulfato)- β-Cyclodextrin
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Phuong Nuyen Thi
Lee Kyung-Ah
Lee Kyoung-Ho
Choi Jung-Kap
Kim Jong-Moon
Kang Jong-Seong
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Abstract
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The -blockers possess at least one chiral center and the S(-)-enantiomer shows higher affinity for binding to the -adrenergic receptors than antipode. The stability constants of acebutolol, celiprolol, propranolol and terbutaline in the inclusion complexes with single-isomer heptakis (2,3-dimethyl-6-sulfato)- -cyclodextrin (HDMS--CD) were determined by capillary electrophoresis. The approximation and linear double reciprocal methods were adapted with comparable results. Among the -blockers studied, propranolol had the lowest stability constant but the highest enantioselectivity, indicating that the magnitudes of the stability constants carried little information about enantioseparation. The magnitudes of enantioselectivities between the enantiomer pair were in the order of propranolol > celiprolol > terbutaline > acebutolol.
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KEYWORD
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Stability constant, β-Blockers, Heptakis (2, 3-dimethyl-6-sulfato- β-cyclodextrin, Capillary electrophoresis)
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